Fitness & Nutrition News

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fitness 18 hours ago

Association of the combined atherosclerosis index of plasma and frailty index with arthritis in middle-aged and older adults: a cohort study

The Atherogenic Index of Plasma (AIP) is a marker of atherosclerosis, and the Frailty Index (FI) reflects physiological decline. The combined effect of AIP and FI remains insufficiently studied. This study aimed to investigate the association between a combined AIP-FI measure and the risk of arthritis. This study utilized data from the China Health and Retirement Longitudinal Study (CHARLS) database between 2011 and 2020. A total of 4437 participants aged ≥ 45 years without arthritis at baseline were included. Cox proportional hazards regression models and restricted cubic spline (RCS) models were employed to explore the relationship between the AIP-FI and the risk of incident arthritis. Over a 10-year follow-up period, a total of 1470 participants developed arthritis, with an incidence rate of 33.13%. Cox regression analysis revealed that each 1-unit increase in AIP-FI was associated with a 3% increase in arthritis risk (HR = 1.03; 95% CI: 1.02 to 1.04). Participants in the highest tertile (T3) of AIP-FI had a 55% higher risk compared to those in the lowest tertile (T1) (HR = 1.55; 95% CI: 1.35 to 1.78). The RCS curve demonstrated a significant nonlinear positive association between AIP-FI and arthritis risk (P for overall < 0.001, P for nonlinear < 0.001). This study indicates that a higher AIP-FI is significantly associated with an increased risk of arthritis. By integrating metabolic and frailty data, the AIP-FI was associated with arthritis risk and may help identify older Chinese adults at higher risk. However, these findings require further validation in independent cohorts before any clinical consideration.

fitness 18 hours ago

Key Milestone Achieved: NDA for Sumecigrel Capsule, an Antiplatelet Innovative Drug by Vcare PharmaTech, Officially Accepted

NANJING, China, June 26, 2026 /PRNewswire/ -- Recently, the NDA for Sumecigrel Capsule (formerly known as Vicagrel), a Class 1 innovative antiplatelet drug developed by Jiangsu Vcare PharmaTech Co.,Ltd. (Vcare PharmaTech), has been officially accepted by the NMPA. The drug has now entered the NDA stage. As a global pioneer in novel antiplatelet agents, Sumecigrel is expected to provide a new and improved treatment option to tens of millions of patients with cardiovascular and cerebrovascular diseases.

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Achievement Unlocked!