Fitness & Nutrition News

WASHINGTON – You've likely heard it since childhood: Don't scratch that bug bite or rash, you'll make it worse. But why would something that feels so good be bad?A lot of things can cause itchiness, sometimes serious diseases. Whatever the cause, doctors have long warned that scratching too much can damage the skin. Now researchers better understand why even a...

Over 84,000 cases are registered nationwide, but experts estimate the true burden could be as high as 369,000 undetected cases.

Half a century after Ebola first shocked the world, the current outbreak shows why scary viruses are not always the biggest pandemic threat R

New parents often struggle in silence, but a growing number of perinatal clinics offering free mental health support are being rolled out across Australia.

BAHAWALPUR: Two more monkeypox suspects were admitted to the Bahawal Victoria Hospital (BVH) on Saturday.

Summer heat raises the risk of kidney stones, yet low awareness leaves many seeking treatment only after severe pain strikes.

Ischemic stroke remains the leading disease in terms of global disability and fatality rates. Cerebral ischemia-reperfusion injury (CIRI) and neuroinflammation induced by CIRI represents a challenge for clinical therapy of ischemic stroke. Epigallocatechin-3-gallate (EGCG), the predominant catechin in green tea, is known to mitigate ischemic stroke and inflammation, while its role in regulating neuroinflammation post-recanalization remains unclear. This study aimed to explore the effect and mechanism of EGCG on the regulation of CIRI. The CIRI in vivo model was established by middle cerebral artery occlusion/reperfusion (MCAO/R) in rats and EGCG was administered via intracerebroventricular injection before MCAO/R. The neurological scores, infarct volume, neuronal injury, and microglial biomarkers were evaluated. BV2 cells subjected to oxygen–glucose deprivation/reoxygenation (OGD/R) were used to establish an in vitro CIRI model. After pretreatment with EGCG and/or ML385, OGD/R, cell viability, microglial biomarkers, pro-inflammatory and anti-inflammatory factors, and transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) and hemeoxygenase-1 (HO-1) were detected. Different conditioned media collected from BV2 cells were used for culturing the neuronal mimic cell line SH-SY5Y. EGCG administration in vivo significantly improved neurological deficits, infarct volume, and neuronal damage. Moreover, pretreatment with EGCG significantly increased BV2 cells viability and anti-inflammatory factors, and reduced toxicity and ferroptosis in SH-SY5Y cells. Furthermore, the upregulation of M2 markers was consistent with in vivo experiments. However, this protective effect was abolished by ML385, an Nrf2 inhibitor. EGCG upregulated Nrf2 and HO-1 protein expression, thus promoting microglial polarization toward the M2 phenotype. EGCG has a protective effect on CIRI by promoting the polarization of microglia toward the M2 phenotype via the Nrf2/HO-1 pathway to inhibit ferroptosis of neuron, which may provide a novel target for ischemic stroke treatment.

Burnout is becoming the new normal at work, but chronic stress silently damages your metabolism, sleep, heart health, and overall wellness.

...living with epilepsy are teachers, doctors, engineers, entrepreneurs, artists, students, parents, and community leaders.

Chandigarh: The Adult and elderly Vaccination Clinic was inaugurated by   Governor  Gulab Chand Kataria ji at Govt. Medical College Hospital, Chandigarh on Saturday.  The clinic will be run by Rotary Club Chandigarh Central in collaboration with the Deptt. of Community Medicine, GMCH, Chandigarh. Adult immunization services will cater to influenza, pneumococcal pneumonia, hepatitis A and B, typhoid, tetanus, shingles and Human Papillomavirus (HPV) continue to cause serious illness, hospitalization and preventable deaths among adults every year. Many of these could be avoided with timely vaccination. See also  Limit industrial exploitation of the natureIt will be a one stop platform where adults/elderly can receive a personalized vaccine assessment