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DAR ES SALAAM: WALKING away from any kind of addiction is not easy as it requires the concerned person to fully commit to the quitting decision in order not to return back to the old bad path. It is something that needs to come from the bottom of the heart meaning that you can hardly
New nicotine products are fueling a crisis among Nigerian youth, exploiting legal loopholes and creating a new generation of addicts. Learn more here.
A large-scale study found early waking schedules and getting regular physical activity were both associated with a reduced risk of developing ALS.
Men’s Fitness aims to feature only the best products and services. If you buy something via one of our links, we may earn a commission. Meal timing has become nutrition’s favorite battlefield. Some sw...
After overcoming cancer as a child, scans revealed her heart was "working under half of what it should".
Marine green algae undergo substantial metabolic shifts during laboratory culture, yet the underlying biochemical mechanisms remain poorly understood. This study aimed to investigate the green seaweed Acrosiphonia orientalis’s multi-approach anti-proliferative and immunomodulatory activities by comparing extracts from laboratory-acclimatized (LabAO) and wild-harvested (WildAO) seaweed samples against human colorectal carcinoma (HCT-116) cell line. Higher accumulation of stress-response metabolites, including phytol, protocatechuic acid, neophytadiene, DHA, and EPA was observed in wild type extract (WildAO). In contrast, extract of lab-acclimatized biomass (LabAO) showed higher accumulation of storage metabolites like trehalose, maltose, and monoolein, as well as essential amino acids such as phenylalanine and isoleucine. Specifically, LabAO had more total sugars, phenolics, chlorophyll, and carotenoids, while WildAO had a higher concentration of flavonoids and proteins. Cancer-linked gene expression analysis revealed that both extracts triggered apoptosis as elevated PRKAA1 and IRS1 gene expression while suppressed SLC2A2 expression, leading to starved cells for energy. Further, GPX1 and SOD2 gene expression declined supporting oxidative stress. High expression of CASP3, TP53 and NDRG1 gene expression showed that cells pushed toward programmed death. Interestingly, expression pattern of NFKB1, MYC and BCL2 showed immunomodulatory activity. These findings highlight the potential of anti-proliferative and immunomodulatory activity, which may further explore for pharmaceuticals and nutraceuticals.
Today, in the second part of this unmissable series, we'll see how making changes to our daily food choices and sleeping habits can also pay big dividends for our memory and cognitive function
Working as executive director of a non-profit organisation, sitting on several boards and being a docent at a museum, Terry Aretz was 'a real go-getter'.
A recent study has revealed new insights into the lipid […]
Rochester, N.Y. It’s National Disorders Awareness Week, and the U of R School of Nursing is hosting several events, including the “Voices of Hope” event.